Vol. 60, 09/2006: Process Chemistry

Table of Contents
514 | PDF | Table of Contents
H. -R. Marti, J.S. Siegel
516 | PDF | Editorial
Early Process Development: The Wyeth Approach
M.K. O’Brien*, M. Kolb*, K. Sutherland, K. McCoy, A. Pilcher
518 | Online Article | Scientific Articles
Process Development for Active Pharmaceutical Ingredients Following a Developmental Cascade
C. Adler, J. Brunner, C. Fichtner, P. Küng, M.K. Levis, H.-R. Ruchti, A. Sjöberg, B. Weber*
523 | Online Article | Scientific Articles
Process Development and Production Concepts for the Manufacturing of Organic Fine Chemicals at LONZA
G. Heckmann, F. Previdoli, T. Riedel, D. Ruppen, D. Veghini*, U. Zacher
530 | Online Article | Scientific Articles
Laboratory for Process Research – Ten Years of Successful Partnership between University of Zurich and the Pharmaceutical Industry
T. Bader
534 | Online Article | Scientific Articles
A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores
J.T. Kuethe
543 | Online Article | Scientific Articles
Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate
B.M. Andresen, S. Caron, M. Couturier*, K.M. DeVries, N.M. Do, K. Dupont-Gaudet, A. Ghosh*, M. Girardin, J.M. Hawkins, T.M. Makowski, M. Riou, J.E. Sieser, J.L. Tucker, B.C. Vanderplas, T.J.N. Watson
554 | Online Article | Scientific Articles
With Asymmetric Hydrogenation Towards a New, Enantioselective Synthesis of Orlistat
R. Birk, M. Karpf, K. Püntener*, M. Scalone, M. Schwindt, U. Zutter
561 | Online Article | Scientific Articles
The Formation of a Crystalline Oxazolidin-5-one from (l)-Alanine and its Use as a Chiral Template in the Practical Synthesis of α-Substituted Alanine Esters
M. Eriksson*, E. Napolitano, J. Xu, S. Kapadia, D. Byrne, L. Nummy, N. Grinberg, S. Shen, H. Lee, V. Farina
566 | Online Article | Scientific Articles
Recent Optimization Highlights of the Georgywood Process
J.-P. Barras, B. Bourdin, F. Schröder*
574 | Online Article | Scientific Articles
An Asymmetric Synthesis of PPAR-γ Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate
J.R. Rizzo T.Y. Zhang*
580 | Online Article | Scientific Articles
The Chemical Development of CHIR-258
S. Zhu*, E. Harwood, S. Cai, X. Shang, G. Galvin, L. Jin, A. Yeung, B. Diaz, M. Zheng, D. Ryckman
584 | Online Article | Scientific Articles
An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1- (2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate
N. Kolla, C.R. Elati, P.J. Vankawala, S. Gangula, E. Sajja, Y. Anjaneyulu, A. Bhattacharya, V. Sundaram, V.T. Mathad*
593 | Online Article | Scientific Articles
The Development of API Manufacturing Processes – Targets and Strategies
D. Wieckhusen
598 | Online Article | Scientific Articles
Data-Oriented Process Development: Determination of Reaction Parameters by Small-Scale Calorimetry with in situ Spectroscopy
G. Puxty, U. Fischer, M. Jecklin, K. Hungerbühler*
605 | Online Article | Scientific Articles
Cost Analysis of a Commercial Manufacturing Process of a Fine Chemical Compound using Micro Process Engineering
U. Krtschil, V. Hessel*, D. Kralisch, G. Kreisel, M. Küpper, R. Schenk
611 | Online Article | Scientific Articles
Continuous Chemistry in Microreaction Systems for Practical Use
G. Müller, T. Gaupp, F. Wahl, G. Wille*
618 | Online Article | Scientific Articles
Simulated Moving Bed Technology for the Industrial Small and Mid Scale Separation of Racemates
P. Kaiser
623 | Online Article | Scientific Articles
Process Research in the Ivory Tower
N.S. Finney
628 | Online Article | Scientific Articles
Using Bacteria to Quantify Arsenic Contamination in Potable Water (Highlights of analytical chemistry in Switzerland)
J.R. van der Meer*, M. Berg, P.T.K. Trang
631 | Online Article | Scientific Articles
Ausserordentliche Generalversamlung der SCG
633 | PDF | News & Events
News - Lectures - Conferences
634 | PDF | News & Events
CHIMIA - Report
636 | PDF | Chimia Report