CHIMIA

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CHIMIA, Vol. 60, Issue 09/2006

Early Process Development: The Wyeth Approach

Process Development for Active Pharmaceutical Ingredients Following a Developmental Cascade

Process Development and Production Concepts for the Manufacturing of Organic Fine Chemicals at LONZA

Laboratory for Process Research – Ten Years of Successful Partnership between University of Zurich and the Pharmaceutical Industry

A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores

Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

With Asymmetric Hydrogenation Towards a New, Enantioselective Synthesis of Orlistat

The Formation of a Crystalline Oxazolidin-5-one from (l)-Alanine and its Use as a Chiral Template in the Practical Synthesis of α-Substituted Alanine Esters

Recent Optimization Highlights of the Georgywood Process

An Asymmetric Synthesis of PPAR-γ Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

The Chemical Development of CHIR-258

An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1- (2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate

The Development of API Manufacturing Processes – Targets and Strategies

Data-Oriented Process Development: Determination of Reaction Parameters by Small-Scale Calorimetry with in situ Spectroscopy

Cost Analysis of a Commercial Manufacturing Process of a Fine Chemical Compound using Micro Process Engineering

Continuous Chemistry in Microreaction Systems for Practical Use

Simulated Moving Bed Technology for the Industrial Small and Mid Scale Separation of Racemates

Process Research in the Ivory Tower

Using Bacteria to Quantify Arsenic Contamination in Potable Water (Highlights of analytical chemistry in Switzerland)

H. -R. Marti, J.S. Siegel